Name 3 physiologic mechanisms of PU/PD in a Cushingoid animal. Hypercortisolism Name 3 physiologic mechanisms of PU/PD in a Cushingoid animal. - ADH antagonism/decreased secretion - Concurrent diabetes mellitus - Decreased renal tubular water permeability --> decreased water resorption Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+